A research team led by Tomoya Nakazawa of Hamamatsu Photonics (Japan) recently developed a novel methodology to estimate BGLs from NIR measurements. Their work, which could revolutionize noninvasive blood glucose monitoring, was published in the Journal of Biomedical Optics.
The core contribution of this study is a new blood glucose level index that the research team derived from basic NIR formulas. Their approach begins with the extraction of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) signals from NIR measurements. Through the analysis of massive amounts of data on NIR measurements, the researchers realized that the phase delay (asynchronicity) between the low-frequency and oscillating components of HbO2 and Hb signals is closely related to the degree of oxygen consumption during each cardiac cycle, thereby serving as a gauge for metabolism. “This phase delay-based metabolic index, which has not been reported by other researchers, is a scientifically important discovery,” remarks Nakazawa.
https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-29/issue-03/037001/Non-invasive-blood-glucose-estimation-method-based-on-the-phase/10.1117/1.JBO.29.3.037001.full#_=_
