Mitsubishi Tanabe Pharma America, Inc. (MTPA) today announced new findings from two studies of RADICAVA ORS® (edaravone) presented at the Northeast Amyotrophic Lateral Sclerosis Consortium (NEALS) 2024 Annual Meeting. The company presented results from the MT-1186-A04 Study, a Phase 3b extension of the previously reported MT-1186-A02 study which explored the superiority of investigational once daily dosing versus the FDA-approved on/off regimen of RADICAVA ORS in people living with ALS. MTPA also shared results from primary and post-hoc analyses of RADICAVA ORS compared with Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) historical placebo controls, with evidence suggesting treatment with RADICAVA ORS increased survival outcomes and decreased physical function decline versus controls. Poster Presentation: Phase 3b Extension Study MT-1186-A04 to Evaluate the Continued Efficacy and Safety of Radicava ORS® (Oral Edaravone) for up to an Additional 48 Weeks in Patients with Amyotrophic… 

Der Neurofilament-Leichtketten-Assay, den Siemens Healthineers im Rahmen einer Kooperation mit Novartis entwickelt hat, ist ein In-vitro-Diagnostikum zur quantitativen Bestimmung der Neurofilament-Leichtkette (NfL) in Humanserum und -plasma (EDTA). Der Test ist auf dem Atellica IM Analyzer, ADVIA Centaur XP sowie dem ADVIA Centaur XPT System verwendbar. Der NfL-Assay dient in Verbindung mit klinischen, bildgebenden und Laborbefunden als Hilfsmittel zur Identifizierung schubförmiger Multipler Sklerose. Der Neurofilament-Leichtketten-Assay, den Siemens Healthineers im Rahmen einer Kooperation mit Novartis entwickelt, dient der Bestimmung und Quantifizierung der NfL-Konzentration in Humanserum und Plasma. NfL ist ein Biomarker, mit dem sich die Schädigung von Nervenzellen im Liquor und im Blut messen lässt. Veränderte NfL im Blut können mit verschiedenen schweren neurologischen Erkrankungen und deren Folgeschäden in Zusammenhang stehen. https://www.siemens-healthineers.com/de/laboratory-diagnostics/assays-by-diseases-conditions/neurologie/neurofilament-leichtketten-assay

The Leukemia & Lymphoma Society (LLS) will present new data from its Beat AML® Master Clinical Trial and Pediatric Acute Leukemia (PedAL) Master Clinical Trial at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition. The findings from LLS’s convened master clinical trials show great progress and are helping shape the treatment landscape for acute leukemias. Updated results show that more than half of a group of children with relapsed acute leukemias achieved remission after receiving a combination of treatments. Additional data indicate that IDH inhibitors as single agent or in combination with low-intensity therapies may be a viable treatment option for older adults with acute leukemias. LLS will also support its more than 150 funded researchers, as well as more than a dozen current and former LLS Therapy Acceleration Program® (TAP) biotech company partners, who will present…